The effect of polymorphisms (174G> C and 572C> G) on the Interleukin-6 gene in coronary artery disease: a systematic review and meta-analysis

Abstract Background Coronary Artery Disease (CAD) is caused by the blockage of coronary arteries. it argued that there has an association between Interleukin-6 gene and occurrence atherosclerosis, artery disease, Due to short half-life high variability (IL-6), limited studies have been performed on serum levels interleukin-6 with disease. The aim this study investigate relationship IL-6 polymorphisms Methods This was conducted as a meta-analysis selected articles no lower time limit upto March 2020. Articles related subject were obtained searching several data sources,such SID, IranDoc, Scopus, Embase, Web Science (ISI), PubMed, Direct, Google Scholar databases. heterogeneity assessed using I 2 index in Comprehensive Meta-Analysis software. Results GG genotype IL-6174 G> C polymorphism 0.8 odds ratio tended reduce risk CAD 20%. CG genotypes found be 1.16 1.48 times respectively, indicating increasing effect these two genotypes. In IL-6-572 C>G polymorphism, increased 1.21 1.27 CC 15%, considering 0.85. Conclusion showed IL-6174G> (IL-6) 572 genes Moreover, protective effects 174 reported. also confirmed G>C developing CAD. It should noted meta-analytic reported literatures.